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Top FDA Approved Weight Loss Medications: Which One Works Best?

glass vials filled with different colours and light shining through them - rainbow

Did you know? Two thirds of adults in the U.S. struggle with weight management, and for many, achieving sustainable results through diet and exercise without weight loss medications is out of reach. In fact, only one in six overweight adults successfully manage to maintain their weight loss once they achieve it. 

For millions of people, losing weight and keeping it off isn’t just about willpower—it’s about addressing underlying health problems and having the right tools to make it happen. Crash diets and grueling workout plans might offer quick fixes, but they rarely lead to long-term success, leaving many feeling frustrated and stuck in a cycle of ups and downs.

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The good news? Science has changed the game! Thanks to major advancements in medicine, weight loss doesn’t have to feel like an uphill battle anymore. FDA-approved medications like Semaglutide offer a safe, effective, and science-backed way to help you reach your goals—without relying on extreme measures.

Among these breakthrough treatments, Semaglutide (sold under the brand names Ozempic & Wegovy) has taken center stage for its impressive results and easy, once-a-week dosing. But how does it stack up against other options? Let’s take a closer look at the science, the benefits, and why Semaglutide might be the missing piece in your weight loss journey!

Science-Backed Comparisons of FDA-Approved Weight Loss Medications

The landscape of FDA-approved weight loss medications is diverse, offering various approaches to weight management. Here’s how these treatments stack up:

Semaglutide (Wegovy & Ozempic)

How It Works: A GLP-1 receptor agonist, Semaglutide mimics a hormone that regulates appetite and improves blood sugar control.

Efficacy: Clinical trials show weight loss of 15-20% on average.

Additional Info: Helps manage type 2 diabetes, making it an excellent choice for individuals with overlapping conditions.

Phentermine & Topiramate (Qsymia)

How It Works: Combines an appetite suppressant (phentermine) with an anticonvulsant (topiramate).

Efficacy: Produces 5-10% weight loss on average but carries risks of dependency and cardiovascular side effects.

Additional Info: It is highly recommended that the patient also follows a diet and exercise plan to increase the efficacy of the prescription. The list of potential side effects is long and varies greatly depending on the person.

Naltrexone & Bupropion (Contrave)

How It Works: Targets brain reward pathways to reduce hunger and cravings.

Efficacy: Results in a modest ~5% weight loss.

Additional Info: This product is used with a reduced calorie diet and exercise.

Orlistat (Xenical, Alli)

How It Works: Inhibits fat absorption in the gut.

Efficacy: Achieves between 5 – 8% weight loss, though side effects like gastrointestinal discomfort are common.

Additional Info: Evidence shows that it also helps patients who display a presence of risk factors, including hypertension, diabetes, and dyslipidemias.

Liraglutide (Saxenda)

How It Works: Another GLP-1 receptor agonist, similar to Semaglutide but requires daily injections.

Efficacy: Weight loss of 5-10%, slightly less than Semaglutide.

Additional Info: Liraglutide has also shown to significantly reduce the apnea‐hypopnea index (AHI) of patients with sleep apnea.

Tirzepatide (Mounjaro)

How It Works: A dual GIP/GLP-1 receptor agonist, currently approved for type 2 diabetes but showing promising weight loss results in trials.

Efficacy: Early studies indicate weight loss of up to 20% FDA approved for weight loss in November 2023

Additional Info: Some research suggests tirzepatide may offer greater weight loss benefits compared to semaglutide. Its dual mechanism of action could contribute to improved metabolic outcomes. Due to FDA regulations, tirzepatide is not currently available in its generic form however, we offer this medication when we are able.

Why Peak Hydration Offers Semaglutide for Weight Loss 

High Efficacy

Clinical trials consistently rank Semaglutide as one of the most effective FDA-approved medications for weight loss, achieving 15-20% body weight reduction on average.

Convenient Dosing

Unlike the only other GLP-1 receptor agent, Liraglutide which requires daily injections, Semaglutide offers weekly dosing, making it more convenient for weight loss patients.

Dual Benefits

In addition to weight loss, Semaglutide provides excellent blood sugar control, making it ideal for individuals managing type 2 diabetes alongside their weight goals.

Safety Profile

Semaglutide is well-tolerated, with side effects like nausea and fatigue that are generally mild and temporary. It poses fewer risks compared to alternatives like Phentermine, which may cause dependency or cardiovascular issues.

Is Semaglutide Right for You?

Semaglutide is an incredible tool for weight loss, but like any medical treatment, it’s not a one-size-fits-all solution. Your health history, lifestyle, and goals all play a role in determining whether this medication is right for you.

Who Can Benefit from Semaglutide?

This medication may be ideal if you:

  • Have a BMI of 30 or higher (classified as obese).
  • Have a BMI of 27 or higher with weight-related health conditions like type 2 diabetes, high blood pressure, or sleep apnea.
  • Struggle with sustained weight loss despite diet and exercise.
  • Are looking for a medically supervised weight loss solution that is proven to work.

What Results Can You Expect?

While 15-20% body weight reduction is the clinical average, individual results vary based on lifestyle factors, adherence to the program, and overall health. Semaglutide is most effective when combined with:

  • A balanced, nutrient-dense diet
  • Regular physical activity
  • Ongoing medical supervision to track progress

Who Should Avoid It?

This medication isn’t suitable for individuals with:

  • A personal or family history of medullary thyroid cancer.
  • Multiple Endocrine Neoplasia Syndrome Type 2 (MEN2).
  • Certain severe gastrointestinal conditions.
  • Pregnancy or plans to become pregnant soon.

If you’re unsure whether Semaglutide is right for you, the Peak Hydration team is here to guide you through the process with a personalized consultation and a plan tailored to your needs.

Beyond Medication: Free Access to Peak Hydration’s Fitness & Nutrition Program

At Peak Hydration, we believe that long-term success isn’t just about using weight loss medications—it’s about building sustainable habits that support your overall health. That’s why when you enroll in our medically supervised weight loss program, you’ll automatically receive FREE access to our Fitness & Nutrition Program!

What This Means for You:

  • Expert Nutrition Guidance: Discover how to nourish your body with foods that support weight loss and boost energy while embracing intuitive eating—no strict rules or calorie counting required!
  • Fun, Manageable Workouts: Get access to a workout program designed to complement your weight loss journey.
  • Ongoing Support & Accountability: Stay motivated with check-ins, coaching, and a community that’s here to help!

By combining science-backed weight loss treatments with real lifestyle changes, Peak Hydration gives you the tools to achieve lasting results—not just short-term success!

Take the First Step Toward a Healthier You!

Ready to start your weight loss journey with the support of experts and a program designed for real, sustainable results?

Schedule your consultation with Peak Hydration today! Let’s create a plan that works for your body, your goals, and your lifestyle—with the added benefits of expert nutrition and fitness coaching, completely free!

Why Choose Peak Hydration for Your Weight Loss Journey?

At Peak Hydration, we believe that effective weight loss is about more than just using weight loss medications—it’s about a comprehensive, supportive approach that addresses every aspect of your health and well-being. Here’s why our program stands out:

board certified professional administering a wellness shot to a client - Peak Hydration

Expertise You Can Trust: Our entire team and on-staff doctor are all board certified professionals so you know you’re in good hands. Dr. Honey, our team doctor is a medical professional trained to properly and safely manage your medical weight loss.

Personalized, Comprehensive Care: Weight loss isn’t a one-size-fits-all journey, and neither is our approach! Our science-backed, evidence-based weight loss plans are designed with your unique medical history, goals, and needs in mind.

Standard dosing for semaglutide doesn’t work for everyone, which is why our experienced team customizes your treatment to fit your body’s response. Unlike other programs that leave patients to self-inject at home with little support, you’ll receive weekly check-ins with a skilled Registered Nurse (RN) who administers your medication, answers your questions, and provides expert guidance every step of the way–we even offer at-home programs if needed! 

Free Fitness & Nutrition Program: When you join our weight loss program, you’ll also gain complimentary access to our exclusive Fitness & Nutrition Program, designed to enhance your results. 

With our program you’ll get: 

  • Custom workout plans tailored to your fitness level and goals.
  • Expert nutritional guidance to help you fuel your body with the right foods for sustainable weight loss and energy.
  • Ongoing support and accountability to keep you on track and motivated throughout your journey.

A Supportive Environment: From your first consultation to ongoing treatments, we’re dedicated to creating a welcoming, professional space where you feel confident and supported!

By choosing Peak Hydration, you’re not just signing up for a weight loss plan—you’re gaining access to a holistic program that combines the latest in medical science with tools and support for lasting success!

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